| ITGB2 Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrin ITGAL/ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL. Integrins ITGAM/ITGB2 and ITGAX/ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX/ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM/ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM/ITGB2 is also a receptor for factor X. Integrin ITGAD/ITGB2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity. Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation. Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages. In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. Belongs to the integrin beta chain family. Leukocytes (PubMed:23775590). Expressed in neutrophils (at protein level) (PubMed:21193407, PubMed:28807980). Note: This description may include information from UniProtKB. |
| Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. |
| Chromosomal Location of human Ortholog: 21q22.3 |
| Cellular Component: cell surface; external side of plasma membrane; ficolin-1-rich granule membrane; focal adhesion; integrin alphaL-beta2 complex; integrin alphaM-beta2 complex; integrin alphaX-beta2 complex; integrin complex; plasma membrane; plasma membrane raft; receptor complex; specific granule membrane; tertiary granule membrane |
| Molecular Function: amyloid-beta binding; cargo receptor activity; cell adhesion molecule binding; complement component C3b binding; heat shock protein binding; ICAM-3 receptor activity; integrin binding; metal ion binding; protein binding; protein kinase binding |
| Biological Process: amyloid-beta clearance; apoptotic process; cell adhesion; cell adhesion mediated by integrin; cell migration; cell-cell adhesion; cell-cell adhesion via plasma-membrane adhesion molecules; cell-cell signaling; cell-matrix adhesion; cellular response to low-density lipoprotein particle stimulus; endodermal cell differentiation; heterotypic cell-cell adhesion; inflammatory response; integrin-mediated signaling pathway; leukocyte cell-cell adhesion; microglial cell activation; negative regulation of dopamine metabolic process; neutrophil chemotaxis; neutrophil migration; phagocytosis, engulfment; positive regulation of leukocyte adhesion to vascular endothelial cell; positive regulation of neutrophil degranulation; positive regulation of prostaglandin-E synthase activity; positive regulation of protein targeting to membrane; positive regulation of superoxide anion generation; receptor clustering; receptor internalization; receptor-mediated endocytosis; regulation of cell shape; regulation of peptidyl-tyrosine phosphorylation |
| Disease: Leukocyte Adhesion Deficiency, Type I |
| Reference #: P05107 (UniProtKB) |
| Alt. Names/Synonyms: CD18; cell surface adhesion glycoprotein (LFA-1/CR3/P150,959 beta subunit precursor); cell surface adhesion glycoprotein LFA-1/CR3/P150,959 beta subunit precursor); Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; complement component 3 receptor 3 and 4 subunit; complement receptor C3 beta-subunit; Complement receptor C3 subunit beta; integrin beta chain, beta 2; Integrin beta-2; integrin subunit beta 2; integrin, beta 2 (complement component 3 receptor 3 and 4 subunit); ITB2; ITGB2; LAD; LCAMB; leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; LFA-1; MAC-1; MF17; MFI7; truncated integrin beta-2 |
| Gene Symbols: ITGB2 |
| Molecular weight: 84,791 Da |
| Basal Isoelectric point: 6.69 Predict pI for various phosphorylation states |
| CST Pathways: Actin Dynamics | GPCR Signaling to MAPKs | Growth And Differentiation Control by MAPKs | PI3K/Akt Signaling | T Cell Receptor Signaling |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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ITGB2 |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Reactome
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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