gp130 Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize IL6ST for initiating signal transmission. Binding of IL6 to IL6R induces IL6ST homodimerization and formation of a high-affinity receptor complex, which activates Janus kinases. That causes phosphorylation of IL6ST tyrosine residues which in turn activates STAT3. Mediates signals which regulate immune response, hematopoiesis, pain control and bone metabolism. Has a role in embryonic development. Does not bind IL6. Essential for survival of motor and sensory neurons and for differentiation of astrocytes. Required for expression of TRPA1 in nociceptive neurons. Required for the maintenance of PTH1R expression in the osteoblast lineage and for the stimulation of PTH-induced osteoblast differentiation. Required for normal trabecular bone mass and cortical bone composition. Belongs to the type I cytokine receptor family. Type 2 subfamily. Found in all the tissues and cell lines examined (PubMed:2261637). Expression not restricted to IL6 responsive cells (PubMed:2261637). Expressed in blood serum (at protein level) (PubMed:24629561). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 13 D2.2|13 63.73 cM
Cellular Component:  cell body; ciliary neurotrophic factor receptor complex; dendrite; external side of plasma membrane; extracellular space; integral component of membrane; interleukin-6 receptor complex; membrane; neuronal cell body; neuronal cell body membrane; oncostatin-M receptor complex; plasma membrane; receptor complex
Molecular Function:  ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; cytokine binding; cytokine receptor activity; growth factor binding; identical protein binding; protein binding
Biological Process:  ciliary neurotrophic factor-mediated signaling pathway; cytokine-mediated signaling pathway; glycogen metabolic process; interleukin-27-mediated signaling pathway; interleukin-6-mediated signaling pathway; leukemia inhibitory factor signaling pathway; negative regulation of cytosolic calcium ion concentration; negative regulation of interleukin-6-mediated signaling pathway; oncostatin-M-mediated signaling pathway; positive regulation of astrocyte differentiation; positive regulation of cell proliferation; positive regulation of osteoblast differentiation; positive regulation of smooth muscle cell migration; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; regulation of Notch signaling pathway; response to cytokine; signal transduction; triglyceride mobilization
Reference #:  Q00560 (UniProtKB)
Alt. Names/Synonyms: 5133400A03Rik; AA389424; BB405851; CD130; D13Ertd699; D13Ertd699e; gp13; gp130; IL-6 receptor subunit beta; IL-6R subunit beta; IL-6R-beta; IL-6RB; IL6RB; Il6st; interleukin 6 signal transducer; Interleukin-6 receptor subunit beta; Interleukin-6 signal transducer; Membrane glycoprotein 130; Oncostatin-M receptor subunit alpha
Gene Symbols: Il6st
Molecular weight: 102,451 Da
Basal Isoelectric point: 5.35  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene