UNC5A Receptor for netrin required for axon guidance. Functions in the netrin signaling pathway and promotes neurite outgrowth in response to NTN1. Mediates axon repulsion of neuronal growth cones in the developing nervous system in response to netrin. Axon repulsion in growth cones may be mediated by its association with DCC that may trigger signaling for repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Belongs to the unc-5 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis
Chromosomal Location of rat Ortholog: 17p14
Cellular Component:  integral component of membrane; intrinsic component of plasma membrane; membrane raft; neuron projection membrane; neuronal cell body membrane; plasma membrane
Molecular Function:  netrin receptor activity
Biological Process:  anterior/posterior axon guidance; apoptotic process; axon guidance; netrin-activated signaling pathway; neuron projection development
Reference #:  O08721 (UniProtKB)
Alt. Names/Synonyms: Netrin receptor UNC5A; Protein unc-5 homolog 1; Protein unc-5 homolog A; transmembrane receptor Unc5H1; unc-5 homolog 1; unc-5 homolog A (C. elegans); Unc5a; Unc5h1
Gene Symbols: Unc5a
Molecular weight: 98,841 Da
Basal Isoelectric point: 6.48  Predict pI for various phosphorylation states
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UNC5A

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene