CASP9 a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two isoforms. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; EC; Protease
Chromosomal Location of Human Ortholog: 4|4 E1
Cellular Component:  apoptosome; cytoplasm; cytosol; mitochondrion; nucleus; protein-containing complex
Molecular Function:  cysteine-type endopeptidase activity; cysteine-type endopeptidase activity involved in apoptotic process; cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type peptidase activity; hydrolase activity; identical protein binding; peptidase activity; protein binding; protein kinase binding; SH3 domain binding
Biological Process:  activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic process; cellular response to dexamethasone stimulus; cellular response to DNA damage stimulus; cellular response to UV; intrinsic apoptotic signaling pathway in response to DNA damage; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of apoptotic process; positive regulation of neuron apoptotic process; proteolysis; regulation of apoptotic process; regulation of response to DNA damage stimulus; response to organic cyclic compound; response to UV; signal transduction in response to DNA damage
Reference #:  Q8C3Q9 (UniProtKB)
Alt. Names/Synonyms: AI115399; APAF-3; Apoptotic protease Mch-6; Apoptotic protease-activating factor 3; AW493809; Casp9; caspase 9; Caspase-9; Caspase9; ICE-LAP6; ICE-like apoptotic protease 6; Mch6; OTTMUSP00000010525
Gene Symbols: Casp9
Molecular weight: 49,979 Da
Basal Isoelectric point: 6.39  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Apoptosis Regulation  |  Death Receptor Signaling  |  ErbB/HER Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein