TNFL9 Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family. Expressed in brain, placenta, lung, skeletal muscle and kidney. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Cell cycle regulation; Cytokine; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17|17 D
Cellular Component:  extracellular space; integral component of membrane; membrane; plasma membrane
Molecular Function:  cytokine activity; signaling receptor binding; tumor necrosis factor receptor binding; tumor necrosis factor receptor superfamily binding
Biological Process:  immune response; myeloid dendritic cell differentiation; positive regulation of activated T cell proliferation; positive regulation of cytotoxic T cell differentiation; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; regulation of cell proliferation
Reference #:  P41274 (UniProtKB)
Alt. Names/Synonyms: 4-1BB; 4-1BB ligand; 4-1BB-; 4-1BB-L; 4-1BBL; AI848817; Cd137; Cd137l; Cd157l; Ly6; Ly63l; TNFL9; Tnfsf9; tumor necrosis factor (ligand) superfamily, member 9; Tumor necrosis factor ligand superfamily member 9
Gene Symbols: Tnfsf9
Molecular weight: 33,853 Da
Basal Isoelectric point: 5.48  Predict pI for various phosphorylation states
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TNFL9

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein