CAMK2A Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission. Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK2 family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 18 E1|18 34.41 cM
Cellular Component:  axon; calcium- and calmodulin-dependent protein kinase complex; cell projection; cytoplasm; dendrite; dendrite cytoplasm; dendritic spine; glutamatergic postsynaptic density; glutamatergic synapse; mitochondrion; neuron projection; neuronal cell body; postsynaptic cytosol; postsynaptic density; presynaptic cytosol; Schaffer collateral - CA1 synapse; synapse
Molecular Function:  ATP binding; calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; glutamate receptor binding; GTPase activating protein binding; identical protein binding; kinase activity; metal ion binding; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  angiotensin-activated signaling pathway; calcium ion transport; calmodulin dependent kinase signaling pathway; cellular response to interferon-beta; cellular response to type II interferon; dendrite morphogenesis; dendritic spine development; G1/S transition of mitotic cell cycle; ionotropic glutamate receptor signaling pathway; negative regulation of hydrolase activity; NMDA selective glutamate receptor signaling pathway; peptidyl-serine phosphorylation; peptidyl-threonine autophosphorylation; phosphorylation; positive regulation of calcium ion transport; positive regulation of cardiac muscle cell apoptotic process; positive regulation of NF-kappaB transcription factor activity; positive regulation of receptor signaling pathway via JAK-STAT; postsynaptic neurotransmitter receptor diffusion trapping; protein autophosphorylation; protein phosphorylation; regulation of endocannabinoid signaling pathway; regulation of mitochondrial membrane permeability involved in apoptotic process; regulation of neuron migration; regulation of neuronal synaptic plasticity; regulation of neurotransmitter receptor localization to postsynaptic specialization membrane; regulation of neurotransmitter secretion; regulation of protein localization to plasma membrane; regulation of synaptic vesicle docking; response to ischemia
Reference #:  P11798 (UniProtKB)
Alt. Names/Synonyms: alpha-CaMKII; calcium/calmodulin-dependent protein kinase II; calcium/calmodulin-dependent protein kinase II alpha; Calcium/calmodulin-dependent protein kinase type II subunit alpha; calmodulin-dependent kinase II; CaM kinase II subunit alpha; CaMK II; CaMK-II subunit alpha; Camk2a; CaMKII; KCC2A; mKIAA0968; OTTMUSP00000017498; OTTMUSP00000017500; R74975
Gene Symbols: Camk2a
Molecular weight: 54,115 Da
Basal Isoelectric point: 6.61  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene