EHD2 Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 1q21
Cellular Component:  caveola; cytosol; extrinsic component of membrane; intercellular bridge; membrane; microtubule cytoskeleton; perinuclear region of cytoplasm; plasma membrane; recycling endosome membrane
Molecular Function:  ATP binding; calcium ion binding; GTP binding; hydrolase activity; identical protein binding; protein domain specific binding
Biological Process:  cortical actin cytoskeleton organization; endocytic recycling; endocytosis; plasma membrane tubulation; positive regulation of endocytic recycling; positive regulation of myoblast fusion; protein localization to plasma membrane
Reference #:  Q4V8H8 (UniProtKB)
Alt. Names/Synonyms: EH domain-containing protein 2; EH-domain containing 2; Ehd2; MGEPS; putative eps protein
Gene Symbols: Ehd2
Molecular weight: 61,237 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene