EHD2 Plays a role in membrane reorganization in response to nucleotide hydrolysis. Binds to liposomes and deforms them into tubules. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for normal fusion of myoblasts to skeletal muscle myotubes. Binds ATP; does not bind GTP. Note: This description may include information from UniProtKB.
Protein type: Vesicle
Chromosomal Location of Human Ortholog: 1q21
Cellular Component:  caveola; cytosol; extrinsic component of membrane; intercellular bridge; membrane; microtubule cytoskeleton; perinuclear region of cytoplasm; plasma membrane; recycling endosome membrane
Molecular Function:  ATP binding; calcium ion binding; GTP binding; hydrolase activity; protein domain specific binding
Biological Process:  cortical actin cytoskeleton organization and biogenesis; endocytic recycling; endocytosis
Reference #:  Q4V8H8 (UniProtKB)
Alt. Names/Synonyms: EH domain-containing protein 2; EH-domain containing 2; Ehd2; MGEPS; putative eps protein
Gene Symbols: Ehd2
Molecular weight: 61,237 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
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EHD2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene