EEF1A1 iso3 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. Brain, placenta, lung, liver, kidney, pancreas but barely detectable in heart and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; Translation; Translation elongation
Chromosomal Location of Human Ortholog: 6q13
Cellular Component:  cortical actin cytoskeleton; cytoplasm; cytoplasmic side of lysosomal membrane; cytosol; eukaryotic translation elongation factor 1 complex; extracellular region; ficolin-1-rich granule lumen; nucleolus; nucleus; plasma membrane; ruffle membrane; secretory granule lumen
Molecular Function:  calmodulin binding; GTP binding; kinase binding; protein binding; protein kinase binding; translation elongation factor activity; tRNA binding
Biological Process:  cellular response to epidermal growth factor stimulus; neutrophil degranulation; regulation of chaperone-mediated autophagy; regulation of D-erythro-sphingosine kinase activity; translational elongation
Reference #:  Q9NZS6 (UniProtKB)
Alt. Names/Synonyms: EEF1A1; Elongation factor 1-alpha
Gene Symbols: EEF1A1
Molecular weight: 46,269 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
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EEF1A1 iso3

Protein Structure Not Found.


Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene