Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation. Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Widely expressed. Expressed in cells of the zona glomerulosa of the adrenal cortex. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK1 family; EC 126.96.36.199; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Cellular Component: cytoplasm; cytosol; glutamatergic synapse; nucleus; postsynaptic density
Molecular Function: ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; protein binding
Biological Process: negative regulation of protein binding; nucleocytoplasmic transport; positive regulation of dendritic spine development; positive regulation of muscle cell differentiation; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein acetylation; positive regulation of protein export from nucleus; positive regulation of protein serine/threonine kinase activity; positive regulation of synapse structural plasticity; positive regulation of syncytium formation by plasma membrane fusion; positive regulation of transcription by RNA polymerase II; protein phosphorylation; regulation of muscle cell differentiation; regulation of protein binding; regulation of protein localization; regulation of synapse organization; signal transduction