UCP1
Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria. Belongs to the mitochondrial carrier (TC 2.A.29) family. Brown adipose tissue. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial |
Chromosomal Location of human Ortholog: 4q31.1 |
Cellular Component:
mitochondrial inner membrane; mitochondrion
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Molecular Function:
cardiolipin binding; GDP binding; GTP binding; long-chain fatty acid binding; oxidative phosphorylation uncoupler activity; proton transmembrane transporter activity; purine ribonucleotide binding; transmembrane transporter activity
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Biological Process:
adaptive thermogenesis; brown fat cell differentiation; cellular response to cold; cellular response to dehydroepiandrosterone; cellular response to fatty acid; cellular response to hormone stimulus; cellular response to reactive oxygen species; diet induced thermogenesis; mitochondrial transmembrane transport; mitochondrial transport; positive regulation of cold-induced thermogenesis; proton transmembrane transport; regulation of reactive oxygen species biosynthetic process; regulation of transcription by RNA polymerase II; response to cold; response to nutrient levels; response to temperature stimulus
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Disease: Obesity
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Reference #:
P25874
(UniProtKB)
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Alt. Names/Synonyms: Mitochondrial brown fat uncoupling protein 1; SLC25A7; Solute carrier family 25 member 7; Thermogenin; UCP; UCP 1; UCP1; uncoupling protein 1; uncoupling protein 1 (mitochondrial, proton carrier)
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Gene Symbols: UCP1
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Molecular weight:
33,005 Da
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Basal Isoelectric point:
9.26
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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