RAPGEF1 Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth. Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 2 B|2 20.32 cM
Cellular Component:  cytoplasm; early endosome; perinuclear region of cytoplasm; phagocytic vesicle membrane; protein-containing complex
Molecular Function:  guanyl-nucleotide exchange factor activity; protein binding; Rap guanyl-nucleotide exchange factor activity; SH3/SH2 adaptor activity
Biological Process:  activation of GTPase activity; blood vessel development; cell-cell adhesion; cellular response to cAMP; cellular response to nerve growth factor stimulus; establishment of endothelial barrier; negative regulation of canonical Wnt signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of neural precursor cell proliferation; negative regulation of protein kinase B signaling; negative regulation of Ras protein signal transduction; nerve growth factor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of ERK1 and ERK2 cascade; positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis; positive regulation of GTPase activity; positive regulation of neuron projection development; Rap protein signal transduction; regulation of cell junction assembly; regulation of JNK cascade
Reference #:  Q91ZZ2 (UniProtKB)
Alt. Names/Synonyms: 4932418O06Rik; C3G; Grf2; Guanine nucleotide exchange factor; guanine nucleotide releasing factor 2; OTTMUSP00000012961; Rap guanine nucleotide exchange factor (GEF) 1; Rapgef1
Gene Symbols: Rapgef1
Molecular weight: 121,923 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Growth And Differentiation Control by MAPKs  |  Insulin Receptor Signaling
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RAPGEF1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein