MDH1 Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the cytoplasm and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Nov 2010]
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC; EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 11 A3.1|11 13.89 cM
Cellular Component:  cytoplasm; cytosol; extracellular space; mitochondrion; myelin sheath
Molecular Function:  catalytic activity; L-malate dehydrogenase activity; malate dehydrogenase activity; NAD binding; oxidoreductase activity; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process:  carbohydrate metabolic process; carboxylic acid metabolic process; malate metabolic process; NAD metabolic process; NADH metabolic process; oxaloacetate metabolic process; tricarboxylic acid cycle
Reference #:  P14152 (UniProtKB)
Alt. Names/Synonyms: B230377B03Rik; Cytosolic malate dehydrogenase; D17921; malate dehydrogenase 1, NAD (soluble); Malate dehydrogenase, cytoplasmic; malate dehydrogenase, soluble; MDH-s; Mdh1; MDHA; MDHC; Mor-2; Mor2; OTTMUSP00000005426
Gene Symbols: Mdh1
Molecular weight: 36,511 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene