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EGFL7
Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 9q34.3 |
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Cellular Component:
cell surface; extracellular region; extracellular space
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Molecular Function:
calcium ion binding; protein binding; signaling receptor binding
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Biological Process:
anatomical structure development; angiogenesis; blood vessel development; cell adhesion; negative regulation of Notch signaling pathway; positive regulation of endothelial cell proliferation; vasculogenesis
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Reference #:
Q9UHF1
(UniProtKB)
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Alt. Names/Synonyms: EGF like domain multiple 7; EGF-like protein 7; EGF-like-domain, multiple 7; EGFL7; Epidermal growth factor-like protein 7; MEGF7; MGC111117; Multiple EGF-like domains protein 7; Multiple epidermal growth factor-like domains protein 7; NEU1; NEU1 protein; NOTCH4-like protein; RP11-251M1.2; Vascular endothelial statin; VE-statin; Zneu1
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Gene Symbols: EGFL7
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Molecular weight:
29,618 Da
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Basal Isoelectric point:
8.58
Predict pI for various phosphorylation states
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