Etk a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.2; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group; Tec family
Chromosomal Location of Human Ortholog: X|X F5
Cellular Component:  cytoplasm; extrinsic component of cytoplasmic side of plasma membrane; nucleoplasm; plasma membrane
Molecular Function:  ATP binding; kinase activity; metal ion binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; receptor binding; transferase activity
Biological Process:  adaptive immune response; apoptosis; B cell receptor signaling pathway; cell adhesion; cell differentiation; innate immune response; peptidyl-tyrosine autophosphorylation; phosphorylation; protein amino acid phosphorylation; protein autophosphorylation; regulation of cell proliferation; signal transduction; T cell receptor signaling pathway; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P97504 (UniProtKB)
Alt. Names/Synonyms: Bmx; BMX non-receptor tyrosine kinase; Bone marrow tyrosine kinase gene in chromosome X protein homolog; Cytoplasmic tyrosine-protein kinase BMX; Etk; Etk/Bmx; OTTMUSP00000021031; Tyro8; TYRO8 protein tyrosine kinase 8
Gene Symbols: Bmx
Molecular weight: 75,001 Da
Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
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Etk

Protein Structure Not Found.


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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene