Myb Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 10 A3|10 9.75 cM
Cellular Component:  cytosol; nucleus
Molecular Function:  DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; WD40-repeat domain binding
Biological Process:  B cell differentiation; calcium ion transport; cellular response to interleukin-6; cellular response to leukemia inhibitory factor; chromatin remodeling; embryonic digestive tract development; G1/S transition of mitotic cell cycle; homeostasis of number of cells; in utero embryonic development; mitotic cell cycle; myeloid cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of transcription, DNA-templated; positive regulation of histone H3-K4 methylation; positive regulation of histone H3-K9 methylation; positive regulation of T-helper cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of gene expression; regulation of transcription, DNA-templated; spleen development; stem cell division; thymus development
Reference #:  P06876 (UniProtKB)
Alt. Names/Synonyms: AI550390; c-myb; gag-myb protein; M16449; MGC18531; Myb; myb proto-oncogene protein; myeloblastosis oncogene; myeloblastosis proto-oncogene product; Proto-oncogene c-Myb; Transcriptional activator Myb; tumor-specific myb protein
Gene Symbols: Myb
Molecular weight: 71,422 Da
Basal Isoelectric point: 6.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Myb

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene