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PPIL3
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved in pre-mRNA splicing. Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily. Ubiquitous. Detected at low levels. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cyclophilin; EC 5.2.1.8; Isomerase; Spliceosome |
| Chromosomal Location of human Ortholog: 2q33.1 |
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Cellular Component:
catalytic step 2 spliceosome; nucleoplasm
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Molecular Function:
peptidyl-prolyl cis-trans isomerase activity; protein binding
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Biological Process:
mRNA splicing, via spliceosome; protein folding; protein peptidyl-prolyl isomerization
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Reference #:
Q9H2H8
(UniProtKB)
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Alt. Names/Synonyms: Cyclophilin J; cyclophilin-like protein 3; Cyclophilin-like protein PPIL3; CyPJ; Peptidyl-prolyl cis-trans isomerase-like 3; peptidylprolyl cis-trans isomerase-like protein 3; peptidylprolyl isomerase (cyclophilin)-like 3; peptidylprolyl isomerase like 3; PPIase; PPIase-like protein 3; PPIL3; Rotamase PPIL3
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Gene Symbols: PPIL3
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Molecular weight:
18,155 Da
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Basal Isoelectric point:
6.29
Predict pI for various phosphorylation states
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