PRDM1 Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. Belongs to the class V-like SAM-binding methyltransferase superfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding; Methyltransferase, protein lysine, predicted; Transcription regulation; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 10 B2|10 23.24 cM
Cellular Component:  cytoplasm; nucleus
Molecular Function:  chromatin DNA binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding; metal ion binding; methyltransferase activity; nucleic acid binding; promoter-specific chromatin binding; protein binding; RNA polymerase II proximal promoter sequence-specific DNA binding; RNA polymerase II regulatory region sequence-specific DNA binding; sequence-specific DNA binding; transferase activity
Biological Process:  adaptive immune response; aorta development; artery morphogenesis; cardiac septum development; cell fate commitment; coronary vasculature development; embryonic placenta development; eye photoreceptor cell development; germ cell development; heart valve development; immune system process; in utero embryonic development; innate immune response; intestinal epithelial cell development; maternal placenta development; methylation; morphogenesis of a branching structure; multicellular organism development; negative regulation of B cell proliferation; negative regulation of gene expression; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription by RNA polymerase II; positive regulation of B cell differentiation; positive regulation of gene expression; post-embryonic development; regulation of cell proliferation; regulation of extrathymic T cell differentiation; regulation of natural killer cell differentiation; regulation of NK T cell differentiation; sebum secreting cell proliferation; trophoblast giant cell differentiation; ventricular septum development
Reference #:  Q60636 (UniProtKB)
Alt. Names/Synonyms: B lymphocyte induced maturation protein; Beta-interferon gene positive regulatory domain I-binding factor; BLIMP-1; Blimp1; PR domain containing 1, with ZNF domain; PR domain zinc finger protein 1; PR domain-containing protein 1; PRDI-BF1; Prdm1; ZNFPR1A1
Gene Symbols: Prdm1
Molecular weight: 95,836 Da
Basal Isoelectric point: 8.85  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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PRDM1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene