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BKR2
Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. Bradykinin receptor subfamily. BDKRB2 sub-subfamily. Ubiquitous. Widespread in normal smooth muscle tissue and neurons. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of mouse Ortholog: 12 E|12 55.76 cM |
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Cellular Component:
endosome; Golgi apparatus; intracellular membrane-bounded organelle; membrane; plasma membrane
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Molecular Function:
beta-2 adrenergic receptor binding; bradykinin receptor activity; G protein-coupled receptor activity; protease binding; protein heterodimerization activity; type 1 angiotensin receptor binding
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Biological Process:
acute inflammatory response to antigenic stimulus; arachidonic acid secretion; G protein-coupled receptor signaling pathway; intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator; maintenance of blood-brain barrier; negative regulation of blood pressure; negative regulation of cell population proliferation; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator; negative regulation of peptidyl-serine phosphorylation; positive regulation of cytosolic calcium ion concentration; response to salt stress; signal transduction; smooth muscle contraction; vasoconstriction; vasodilation
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Reference #:
P32299
(UniProtKB)
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Alt. Names/Synonyms: B(2); B2; B2 bradykinin receptor; B2R; Bdkrb2; BK-2; BK-2 receptor; BK2; BK2R; BKR2; BKRB2; bradykinin receptor, beta 2; BRB2; kinin B2
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Gene Symbols: Bdkrb2
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Molecular weight:
44,389 Da
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Basal Isoelectric point:
8.74
Predict pI for various phosphorylation states
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