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BID
The major proteolytic product p15 BID allows the release of cytochrome c. Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level). 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Apoptosis; Mitochondrial |
| Chromosomal Location of human Ortholog: 22q11.21 |
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Cellular Component:
cytosol; membrane; mitochondrial outer membrane; mitochondrion
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Molecular Function:
death receptor binding; protein binding; ubiquitin protein ligase binding
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Biological Process:
activation of cysteine-type endopeptidase activity involved in apoptotic process; apoptotic mitochondrial changes; establishment of protein localization to membrane; extrinsic apoptotic signaling pathway via death domain receptors; hepatocyte apoptotic process; mitochondrial ATP synthesis coupled electron transport; mitochondrial outer membrane permeabilization; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; neuron apoptotic process; positive regulation of apoptotic process; positive regulation of extrinsic apoptotic signaling pathway; positive regulation of fibroblast apoptotic process; positive regulation of intrinsic apoptotic signaling pathway; positive regulation of mitochondrial membrane potential; positive regulation of protein-containing complex assembly; positive regulation of release of cytochrome c from mitochondria; protein targeting to mitochondrion; protein-containing complex assembly; regulation of epithelial cell proliferation; regulation of G1/S transition of mitotic cell cycle; regulation of T cell proliferation; release of cytochrome c from mitochondria; signal transduction in response to DNA damage; supramolecular fiber organization
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Reference #:
P55957
(UniProtKB)
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Alt. Names/Synonyms: apoptic death agonist; BH3 interacting domain death agonist; BH3-interacting domain death agonist; BH3-interacting domain death agonist p11; BH3-interacting domain death agonist p13; BH3-interacting domain death agonist p15; BID; BID isoform ES(1b); BID isoform L(2); BID isoform Si6; desmocollin type 4; FP497; Human BID coding sequence; MGC15319; MGC42355; p11 BID; p13 BID; p15 BID; p22 BID
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Gene Symbols: BID
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Molecular weight:
21,995 Da
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Basal Isoelectric point:
5.27
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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Death Receptor Signaling
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Inhibition of Apoptosis
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Mitochondrial Control of Apoptosis
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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