PINX1 Microtubule-binding protein essential for faithful chromosome segregation. Mediates TRF1 and TERT accumulation in nucleolus and enhances TRF1 binding to telomeres. Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. Belongs to the PINX1 family. Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Nucleolus; Tumor suppressor
Chromosomal Location of human Ortholog: 8p23.1
Cellular Component:  chromosome, telomeric region; condensed chromosome kinetochore; kinetochore; nuclear chromosome; nuclear chromosome, telomeric region; nucleolus; spindle
Molecular Function:  protein binding; protein-containing complex binding; telomerase inhibitor activity; telomerase RNA binding
Biological Process:  mitotic metaphase plate congression; negative regulation of cell proliferation; negative regulation of G2/M transition of mitotic cell cycle; negative regulation of protein ubiquitination; negative regulation of telomerase activity; negative regulation of telomere maintenance via telomerase; negative regulation of telomere maintenance via telomere lengthening; positive regulation of protein localization to nucleolus; positive regulation of telomeric DNA binding; protein localization to chromosome, telomeric region; protein localization to nucleolus; regulation of protein stability; regulation of telomerase activity; telomere maintenance via telomerase
Reference #:  Q96BK5 (UniProtKB)
Alt. Names/Synonyms: 67-11-3 protein; FLJ20565; Gno1; hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTL; LPTS; MGC8850; PIN2 (TERF1) interacting telomerase inhibitor 1; PIN2-interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; PINX1; Protein 67-11-3; Pxr1; TRF1-interacting protein 1
Gene Symbols: PINX1
Molecular weight: 37,035 Da
Basal Isoelectric point: 9.61  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB