SNCB a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May play a role in neuronal plasticity, is abundant in neurofibrillary lesions of Alzheimer's patients. Highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 13 B1|13 29.28 cM
Cellular Component:  axon terminus; cytoplasm; growth cone; inclusion body; neuronal cell body; presynaptic cytosol; synapse; terminal bouton
Molecular Function:  alpha-tubulin binding; beta-tubulin binding; calcium ion binding; cuprous ion binding; transition metal ion binding
Biological Process:  chemical synaptic transmission; dopamine metabolic process; negative regulation of neuron apoptotic process; synapse organization; synaptic vesicle endocytosis
Reference #:  Q91ZZ3 (UniProtKB)
Alt. Names/Synonyms: AI838531; Beta-synuclein; betaSYN; Sncb; synuclein, beta; SYUB
Gene Symbols: Sncb
Molecular weight: 14,052 Da
Basal Isoelectric point: 4.38  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene