Bcl-xL Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release. Isoform Bcl-X(S) promotes apoptosis. Belongs to the Bcl-2 family. Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial
Chromosomal Location of Human Ortholog: 2 75.41 cM|2 H1
Cellular Component:  Bcl-2 family protein complex; cell junction; centrosome; cytoplasm; cytoplasmic vesicle; cytoskeleton; cytosol; endoplasmic reticulum; integral component of membrane; membrane; mitochondrial envelope; mitochondrial inner membrane; mitochondrial membrane; mitochondrial outer membrane; mitochondrion; nucleus; presynapse; synapse
Molecular Function:  BH domain binding; BH3 domain binding; clathrin binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; GTPase binding; identical protein binding; MDM2/MDM4 family protein binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein-containing complex binding; transcription factor binding
Biological Process:  apoptotic process; apoptotic process in bone marrow; cell proliferation; cellular process regulating host cell cycle in response to virus; cellular response to alkaloid; cellular response to amino acid stimulus; cellular response to gamma radiation; extrinsic apoptotic signaling pathway in absence of ligand; fertilization; germ cell development; hepatocyte apoptotic process; in utero embryonic development; intrinsic apoptotic signaling pathway in response to DNA damage; male gonad development; mitochondrion morphogenesis; mitotic cell cycle checkpoint; negative regulation of anoikis; negative regulation of apoptotic process; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of execution phase of apoptosis; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; negative regulation of neuron apoptotic process; negative regulation of protein localization to plasma membrane; negative regulation of release of cytochrome c from mitochondria; neuron apoptotic process; ovarian follicle development; positive regulation of apoptotic process; positive regulation of ATP biosynthetic process; positive regulation of cell proliferation; positive regulation of synaptic vesicle clustering; positive regulation of synaptic vesicle endocytosis; positive regulation of synaptic vesicle exocytosis; regulation of apoptotic process; regulation of cytokinesis; regulation of growth; regulation of long-term synaptic depression; regulation of mitochondrial membrane permeability; regulation of mitochondrial membrane potential; release of cytochrome c from mitochondria; response to cycloheximide; response to cytokine; response to ischemia; response to radiation; response to virus; spermatogenesis; suppression by virus of host apoptotic process; synaptic vesicle recycling via endosome
Reference #:  Q64373 (UniProtKB)
Alt. Names/Synonyms: anti-apoptosis regulatory protein; Apoptosis regulator Bcl-X; B-cell leukemia/lymphoma x; B2CL1; Bcl; Bcl(X; Bcl(X)L; bcl-; Bcl-2-like protein 1; bcl-x; Bcl-XL; Bcl-Xs; Bcl2-L-1; BCL2-like 1; Bcl2l; Bcl2l1; Bclx; MGC113803; MGC99998; OTTMUSP00000016850; RP23-106A3.4
Gene Symbols: Bcl2l1
Molecular weight: 26,132 Da
Basal Isoelectric point: 4.87  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene