MCM8 Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8- MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. May also play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC). Binds chromatin throughout the cell cycle. Belongs to the MCM family. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC
Chromosomal Location of Human Ortholog: 20p12.3
Cellular Component:  chromosome; MCM8-MCM9 complex; nucleoplasm; nucleus
Molecular Function:  ATP binding; chromatin binding; DNA binding; enzyme binding; helicase activity; MutLbeta complex binding; MutSalpha complex binding; MutSbeta complex binding; protein binding
Biological Process:  cellular response to DNA damage stimulus; DNA replication; double-strand break repair via homologous recombination; female gamete generation; G1/S transition of mitotic cell cycle; male gamete generation; protein localization to chromatin; protein stabilization; recombinational interstrand cross-link repair
Disease: Premature Ovarian Failure 10
Reference #:  Q9UJA3 (UniProtKB)
Alt. Names/Synonyms: C20orf154; dJ967N21.5; DNA helicase MCM8; DNA replication licensing factor MCM8; MCM8; MCM8 minichromosome maintenance deficient 8; MGC119522; MGC119523; MGC12866; MGC4816; Minichromosome maintenance 8; minichromosome maintenance complex component 8; REC; REC homolog
Gene Symbols: MCM8
Molecular weight: 93,697 Da
Basal Isoelectric point: 7.82  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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