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ZNF259
Acts as a signaling molecule that communicates proliferative growth signals from the cytoplasm to the nucleus. Plays a role for the localization and accumulation of the survival motor neuron protein SMN1 in sub-nuclear bodies, including gems and Cajal bodies. Induces neuron differentiation and stimulates axonal growth and formation of growth cone in spinal cord motor neurons. Plays a role in the splicing of cellular pre-mRNAs. May be involved in H(2)O(2)-induced neuronal cell death. Belongs to the ZPR1 family. Expressed in fibroblast; weakly expressed in fibroblast of spinal muscular atrophy (SMA) patients. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; Nucleolus |
| Chromosomal Location of Human Ortholog: 11q23.3 |
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Cellular Component:
axon; Cajal body; cytoplasm; Gemini of coiled bodies; growth cone; neuronal cell body; nucleolus; nucleoplasm; nucleus; perikaryon; perinuclear region of cytoplasm; SMN complex
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Molecular Function:
protein binding; receptor tyrosine kinase binding; translation initiation factor binding; zinc ion binding
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Biological Process:
apoptotic process involved in development; axon development; Cajal body organization; cellular response to epidermal growth factor stimulus; DNA endoreduplication; inner cell mass cell proliferation; microtubule cytoskeleton organization; mRNA processing; negative regulation of motor neuron apoptotic process; positive regulation of gene expression; positive regulation of growth; positive regulation of protein import into nucleus; positive regulation of RNA splicing; positive regulation of transcription involved in G1/S transition of mitotic cell cycle; pre-mRNA catabolic process; regulation of myelination; RNA splicing; signal transduction; spinal cord development; trophectodermal cell proliferation
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Reference #:
O75312
(UniProtKB)
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Alt. Names/Synonyms: MGC110983; Zinc finger protein 259; Zinc finger protein ZPR1; ZNF259; ZPR1; ZPR1 zinc finger
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Gene Symbols: ZPR1
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Molecular weight:
50,925 Da
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Basal Isoelectric point:
4.66
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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