RHOU Acts upstream of PAK1 to regulate the actin cytoskeleton, adhesion turnover and increase cell migration. Stimulates quiescent cells to reenter the cell cycle. Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Belongs to the small GTPase superfamily. Rho family. Ubiquitously expressed in all tissues examined. Expressed at high levels in the stomach, small intestine, brain, skeletal muscle and placenta. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 8|8 E1
Cellular Component:  cell cortex; cell junction; cell projection; cytoplasm; Golgi apparatus; membrane; plasma membrane
Molecular Function:  GTP binding; GTPase activity; metal ion binding; nucleotide binding; protein kinase binding
Biological Process:  actin cytoskeleton organization; actin filament organization; Cdc42 protein signal transduction; cell projection assembly; cytoskeleton organization; endocytosis; establishment or maintenance of cell polarity; G1/S transition of mitotic cell cycle; Rac protein signal transduction; regulation of actin cytoskeleton organization; regulation of cell shape; Rho protein signal transduction; small GTPase mediated signal transduction
Reference #:  Q9EQT3 (UniProtKB)
Alt. Names/Synonyms: 2310026M05Rik; AI182090; Arhu; CDC42L; CDC42L1; G28k; mG28K; ras homolog family member U; ras homolog gene family, member U; Ras-like protein member U; Rho GTPase-like protein ARHU; Rho-related GTP-binding protein RhoU; RHOU; Wnt-1 responsive Cdc42 homolog 1; Wnt1 responsive Cdc42 homolog; WRCH; WRCH-; WRCH-1; Wrch1
Gene Symbols: Rhou
Molecular weight: 28,354 Da
Basal Isoelectric point: 8.93  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Microtubule Dynamics  |  SAPK/JNK Signaling Cascades
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein