ADRB2 Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: 18 E1|18 35.1 cM
Cellular Component:  apical plasma membrane; axon; caveola; cytoplasm; dendrite; dendritic spine; endosome; glutamatergic synapse; integral component of membrane; integral component of plasma membrane; intracellular membrane-bounded organelle; membrane; neuronal cell body membrane; nucleus; plasma membrane; receptor complex; sarcolemma
Molecular Function:  adenylate cyclase binding; adrenergic receptor activity; amyloid-beta binding; B2 bradykinin receptor binding; beta2-adrenergic receptor activity; dopamine binding; drug binding; enzyme binding; epinephrine binding; G protein-coupled receptor activity; G-protein alpha-subunit binding; ionotropic glutamate receptor binding; norepinephrine binding; potassium channel regulator activity; protein binding; protein homodimerization activity; protein phosphatase 2A binding; protein-containing complex binding; receptor-receptor interaction
Biological Process:  activation of adenylate cyclase activity; adenylate cyclase-activating adrenergic receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; adrenergic receptor signaling pathway; associative learning; bone resorption; brown fat cell differentiation; cellular response to amyloid-beta; cellular response to hypoxia; desensitization of G protein-coupled receptor signaling pathway by arrestin; diaphragm contraction; diet induced thermogenesis; excitatory postsynaptic potential; G protein-coupled receptor signaling pathway; heat generation; negative regulation of angiogenesis; negative regulation of inflammatory response; negative regulation of multicellular organism growth; negative regulation of ossification; negative regulation of platelet aggregation; negative regulation of smooth muscle contraction; negative regulation of urine volume; norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of AMPA receptor activity; positive regulation of apoptotic process; positive regulation of ATPase activity; positive regulation of autophagosome maturation; positive regulation of blood vessel diameter; positive regulation of bone mineralization; positive regulation of calcium ion import across plasma membrane; positive regulation of cell proliferation; positive regulation of cold-induced thermogenesis; positive regulation of heart contraction; positive regulation of lipophagy; positive regulation of MAPK cascade; positive regulation of mini excitatory postsynaptic potential; positive regulation of potassium ion transport; positive regulation of protein kinase A signaling; positive regulation of protein serine/threonine kinase activity; positive regulation of protein ubiquitination; positive regulation of skeletal muscle tissue growth; positive regulation of sodium ion transport; positive regulation of the force of heart contraction by epinephrine; positive regulation of transcription by RNA polymerase II; receptor-mediated endocytosis; regulation of blood vessel diameter; regulation of calcium ion transport; regulation of sensory perception of pain; regulation of smooth muscle contraction; regulation of sodium ion transport; regulation of synaptic vesicle exocytosis; regulation of systemic arterial blood pressure by norepinephrine-epinephrine; response to cold; signal transduction; synaptic transmission, glutamatergic; wound healing
Reference #:  P18762 (UniProtKB)
Alt. Names/Synonyms: Adrb; Adrb-2; Adrb2; Adrb2r; adrenergic receptor, beta 2; Bad; Badm; beta 2-adrenoceptor; beta 2-AR; Beta-2 adrenergic receptor; Beta-2 adrenoceptor; Beta-2 adrenoreceptor; Gpc; Gpcr7
Gene Symbols: Adrb2
Molecular weight: 46,998 Da
Basal Isoelectric point: 7.07  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene