ATF-4 a leucine zipper transcription factor that was isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). Involved in the unfolded protein response (UPR) in which dietary protein deficiency, imbalanced amino acid intake via the amino acid response, or ER stress activate the EIF2AK3-eIF2-ATF4 pathway. In concert with DDIT3, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors. Involved in cisplatin resistance. Other members of the family include AP-1 transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. A member of the bZIP family. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 15 E1|15 37.85 cM
Cellular Component:  ATF1-ATF4 transcription factor complex; ATF4-CREB1 transcription factor complex; centrosome; CHOP-ATF4 complex; cytoplasm; cytoskeleton; Lewy body core; membrane; neuron projection; nuclear periphery; nucleus; plasma membrane; RNA polymerase II transcription factor complex; transcription factor complex
Molecular Function:  DNA binding; DNA binding transcription factor activity; leucine zipper domain binding; protein binding; protein C-terminus binding; protein heterodimerization activity; protein kinase binding; sequence-specific DNA binding; transcription factor binding; transcription regulatory region DNA binding
Biological Process:  cellular calcium ion homeostasis; cellular response to amino acid starvation; cellular response to glucose starvation; circadian regulation of gene expression; circadian rhythm; gamma-aminobutyric acid signaling pathway; gluconeogenesis; mRNA transcription from RNA polymerase II promoter; negative regulation of potassium ion transport; PERK-mediated unfolded protein response; positive regulation of apoptosis; positive regulation of gene expression; positive regulation of neuron apoptotic process; positive regulation of sodium-dependent phosphate transport; positive regulation of transcription from RNA polymerase I promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; positive regulation of transcription, DNA-templated; positive regulation of vascular associated smooth muscle cell apoptotic process; positive regulation of vascular endothelial growth factor production; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-templated; rhythmic process; transcription, DNA-dependent
Reference #:  Q06507 (UniProtKB)
Alt. Names/Synonyms: Activating transcription factor 4; Atf-4; Atf4; C/ATF; C/EBP-related ATF; cAMP-dependent transcription factor ATF-4; CREB2; Cyclic AMP-dependent transcription factor ATF-4; MGC96460; Tax-responsive enhancer element-binding protein 67 homolog; TAXREB67; TaxREB67 homolog
Gene Symbols: Atf4
Molecular weight: 38,355 Da
Basal Isoelectric point: 4.71  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene