ERP44
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1A and ERO1B in the endoplasmic reticulum. Note: This description may include information from UniProtKB.
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Protein type: Endoplasmic reticulum; Isomerase; Secreted; Secreted, signal peptide |
Chromosomal Location of human Ortholog: 9q31.1 |
Cellular Component:
cell surface; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; extracellular region; specific granule lumen
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Molecular Function:
protein binding; protein disulfide isomerase activity
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Biological Process:
cell redox homeostasis; glycoprotein metabolic process; protein folding; response to endoplasmic reticulum stress; response to unfolded protein
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Reference #:
Q9BS26
(UniProtKB)
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Alt. Names/Synonyms: endoplasmic reticulum protein 44; Endoplasmic reticulum resident protein 44; endoplasmic reticulum resident protein 44 kDa; epididymis secretory sperm binding protein; ER protein 44; ERP44; KIAA0573; PDIA10; protein disulfide isomerase family A, member 10; thioredoxin domain containing 4 (endoplasmic reticulum); thioredoxin domain-containing protein 4; TXNDC4
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Gene Symbols: ERP44
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Molecular weight:
46,971 Da
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Basal Isoelectric point:
5.09
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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