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ARAF
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. Predominantly in urogenital tissues. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.1; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RAF family; RAF subfamily; TKL group |
| Chromosomal Location of mouse Ortholog: X A1.3|X 16.3 cM |
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Cellular Component:
cytosol; mitochondrion
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Molecular Function:
ATP binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
MAPK cascade; negative regulation of apoptotic process; phosphorylation; positive regulation of peptidyl-serine phosphorylation; protein phosphorylation; regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of TOR signaling; signal transduction
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Reference #:
P04627
(UniProtKB)
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Alt. Names/Synonyms: 1200013E08Rik; A-raf; A-Raf proto-oncogene serine/threonine-protein kinase; Araf; Araf proto-oncogene, serine/threonine kinase; Araf1; AW495444; OTTMUSP00000018673; Proto-oncogene A-Raf; raf-related oncogene; Serine/threonine-protein kinase A-Raf; v-raf murine sarcoma 3611 viral oncogene homolog; v-raf murine sarcoma 3611 viral oncogene homolog 1
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Gene Symbols: Araf
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Molecular weight:
67,581 Da
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Basal Isoelectric point:
9.27
Predict pI for various phosphorylation states
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CST Pathways:
ErbB/HER Signaling
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ESC Pluripotency and Differentiation
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IL6 Signaling
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Inhibition of Apoptosis
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T Cell Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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