AMPKB1 Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). Belongs to the 5'-AMP-activated protein kinase beta subunit family. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  cytoplasm; nucleotide-activated protein kinase complex; nucleus; protein-containing complex
Molecular Function:  AMP-activated protein kinase activity; protein binding; protein kinase activity; protein kinase binding
Biological Process:  fatty acid biosynthetic process; fatty acid metabolic process; lipid metabolic process; nail development; positive regulation of cold-induced thermogenesis; positive regulation of gene expression; protein heterooligomerization; protein phosphorylation; regulation of catalytic activity
Reference #:  Q9R078 (UniProtKB)
Alt. Names/Synonyms: 1300015D22Rik; 5'-AMP-activated protein kinase subunit beta-1; AAKB1; AMPK subunit beta-1; AMPKb; AMPKB1; AU021155; E430008F22; OTTMUSP00000015612; OTTMUSP00000015613; Prkab1; protein kinase, AMP-activated, beta 1 non-catalytic subunit
Gene Symbols: Prkab1
Molecular weight: 30,308 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene