IL4
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. Belongs to the IL-4/IL-13 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide |
Chromosomal Location of mouse Ortholog: 11 B1.3|11 31.97 cM |
Cellular Component:
external side of plasma membrane; extracellular region; extracellular space
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Molecular Function:
cytokine activity; cytokine receptor binding; growth factor activity; interleukin-4 receptor binding
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Biological Process:
activated T cell proliferation; activation of Janus kinase activity; autophagy; B cell activation; B cell costimulation; B cell proliferation; cholesterol metabolic process; defense response to protozoan; dendritic cell differentiation; extrinsic apoptotic signaling pathway; extrinsic apoptotic signaling pathway in absence of ligand; immune response; innate immune response in mucosa; interleukin-4-mediated signaling pathway; isotype switching to IgE isotypes; isotype switching to IgG isotypes; macrophage activation; MHC class II biosynthetic process; microglial cell activation; myeloid dendritic cell differentiation; negative regulation of acute inflammatory response; negative regulation of cellular response to transforming growth factor beta stimulus; negative regulation of chronic inflammatory response; negative regulation of complement-dependent cytotoxicity; negative regulation of DNA-templated transcription; negative regulation of endothelial cell apoptotic process; negative regulation of epithelial cell migration; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of inflammatory response; negative regulation of macrophage activation; negative regulation of nitric oxide biosynthetic process; negative regulation of osteoclast differentiation; negative regulation of T cell activation; negative regulation of T-helper 17 cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor production; negative regulation of white fat cell proliferation; neuroinflammatory response; peptidyl-tyrosine phosphorylation; positive regulation of activated T cell proliferation; positive regulation of amyloid-beta clearance; positive regulation of ATP biosynthetic process; positive regulation of B cell activation; positive regulation of B cell proliferation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cellular respiration; positive regulation of chemokine production; positive regulation of cold-induced thermogenesis; positive regulation of defense response to virus by host; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of eosinophil chemotaxis; positive regulation of gene expression; positive regulation of immunoglobulin production; positive regulation of interleukin-10 production; positive regulation of interleukin-13 production; positive regulation of isotype switching to IgE isotypes; positive regulation of isotype switching to IgG isotypes; positive regulation of macroautophagy; positive regulation of mast cell degranulation; positive regulation of MHC class II biosynthetic process; positive regulation of mononuclear cell migration; positive regulation of myoblast fusion; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein phosphorylation; positive regulation of reactive oxygen species biosynthetic process; positive regulation of receptor-mediated endocytosis; positive regulation of T cell differentiation; positive regulation of T cell proliferation; positive regulation of T-helper 2 cell cytokine production; positive regulation of transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; regulation of immune response; regulation of proton transport; T cell activation; T cell proliferation; T-helper 1 cell lineage commitment; T-helper 2 cell differentiation; transcription by RNA polymerase II; tyrosine phosphorylation of STAT protein
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Reference #:
P07750
(UniProtKB)
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Alt. Names/Synonyms: B-cell growth factor 1; B-cell IgG differentiation factor; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; IL-4; IL4; interleukin 4; Interleukin-4; Lymphocyte stimulatory factor 1
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Gene Symbols: Il4
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Molecular weight:
15,834 Da
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Basal Isoelectric point:
8.18
Predict pI for various phosphorylation states
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