IL4 Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. Belongs to the IL-4/IL-13 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: Cell cycle regulation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of human Ortholog: 5q31.1

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; interleukin-4 receptor binding; protein binding

Biological Process: activation of Janus kinase activity; B cell costimulation; B cell differentiation; cholesterol metabolic process; dendritic cell differentiation; extrinsic apoptotic signaling pathway in absence of ligand; immune response; innate immune response in mucosa; interleukin-4-mediated signaling pathway; macrophage activation; microglial cell activation; myeloid dendritic cell differentiation; negative regulation of acute inflammatory response; negative regulation of apoptotic process; negative regulation of cellular response to transforming growth factor beta stimulus; negative regulation of chronic inflammatory response; negative regulation of complement-dependent cytotoxicity; negative regulation of DNA-templated transcription; negative regulation of endothelial cell apoptotic process; negative regulation of epithelial cell migration; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of inflammatory response; negative regulation of macrophage activation; negative regulation of neuroinflammatory response; negative regulation of osteoclast differentiation; negative regulation of T-helper 17 cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of tumor necrosis factor production; neuroinflammatory response; positive regulation of amyloid-beta clearance; positive regulation of ATP biosynthetic process; positive regulation of B cell proliferation; positive regulation of cell migration; positive regulation of cell population proliferation; positive regulation of cellular respiration; positive regulation of cold-induced thermogenesis; positive regulation of defense response to virus by host; positive regulation of DNA-templated transcription; positive regulation of eosinophil chemotaxis; positive regulation of gene expression; positive regulation of interleukin-10 production; positive regulation of interleukin-13 production; positive regulation of isotype switching to IgE isotypes; positive regulation of isotype switching to IgG isotypes; positive regulation of macroautophagy; positive regulation of mast cell degranulation; positive regulation of MHC class II biosynthetic process; positive regulation of mononuclear cell migration; positive regulation of myoblast fusion; positive regulation of receptor-mediated endocytosis; positive regulation of T cell differentiation; positive regulation of T cell proliferation; positive regulation of T-helper 2 cell cytokine production; positive regulation of transcription by RNA polymerase II; positive regulation of tyrosine phosphorylation of STAT protein; regulation of immune response; regulation of isotype switching; regulation of phosphorylation; T cell activation; T-helper 2 cell differentiation; type 2 immune response

Disease: Stroke, Ischemic

Reference #: P05112 (UniProtKB)

Alt. Names/Synonyms: B cell growth factor 1; B cell stimulatory factor 1; B-cell stimulatory factor 1; B_cell stimulatory factor 1; BCGF-1; BCGF1; Binetrakin; BSF-1; BSF1; IL-4; IL4; interleukin 4; interleukin 4 variant 2; Interleukin-4; Lymphocyte stimulatory factor 1; Pitrakinra

Gene Symbols: IL4

Molecular weight: 17,492 Da

Basal Isoelectric point: 9.17 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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IL4

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