ARPP-21 Isoform 2 may act as a competitive inhibitor of calmodulin-dependent enzymes such as calcineurin in neurons. Isoform 2 is expressed in brain. Isoform 1 is present in immature thymocytes (at protein level). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of mouse Ortholog: 9 F3|9 62.46 cM
Cellular Component:  cytoplasm
Molecular Function:  calmodulin binding; nucleic acid binding
Biological Process:  cellular response to heat
Reference #:  Q9DCB4 (UniProtKB)
Alt. Names/Synonyms: 0710001E13Rik; AI853636; ARP; ARP21; ARPP-21; Arpp21; cAMP-regulated phosphoprotein 21; cyclic AMP-regulated phosphoprotein, 21; D9Bwg1012e; protein phosphatase 1, regulatory (inhibitory) subunit 1C; R3hdm; R3hdm3; Rcs; Regulator of calmodulin signaling; Tarpp; thymocyte ARPP; Thymocyte cAMP-regulated phosphoprotein
Gene Symbols: Arpp21
Molecular weight: 88,567 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene