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UBXN6
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes. As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation. It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes. Enhanced expression in testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 19p13.3 |
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Cellular Component:
cytoplasm; cytosol; early endosome membrane; endosome; late endosome membrane; lysosomal membrane; membrane; microtubule organizing center; nucleus; protein-containing complex
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Molecular Function:
protein binding
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Biological Process:
endosome to lysosome transport via multivesicular body sorting pathway; ERAD pathway; macroautophagy
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Reference #:
Q9BZV1
(UniProtKB)
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Alt. Names/Synonyms: CTB-50L17.16; DKFZp667D109; FLJ00394; UBX domain containing 1; UBX domain protein 6; UBX domain-containing 1; UBX domain-containing 2; UBX domain-containing protein 1; UBX domain-containing protein 6; UBXD1; UBXDC2; UBXN6
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Gene Symbols: UBXN6
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Molecular weight:
49,754 Da
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Basal Isoelectric point:
6.46
Predict pI for various phosphorylation states
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