FCGR1A High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Belongs to the immunoglobulin superfamily. FCGR1 family. Monocyte/macrophage specific. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 3 F2.1|3 41.72 cM
Cellular Component:  external side of plasma membrane; integral component of membrane; membrane; membrane raft; plasma membrane
Molecular Function:  IgG binding; IgG receptor activity; leukotriene receptor binding
Biological Process:  antibody-dependent cellular cytotoxicity; antigen processing and presentation of exogenous antigen; antigen processing and presentation of exogenous peptide antigen via MHC class I; cell surface receptor signaling pathway; defense response to bacterium; immune system process; innate immune response; phagocytosis, engulfment; phagocytosis, recognition; positive regulation of phagocytosis; positive regulation of phagocytosis, engulfment; positive regulation of protein tyrosine kinase activity; positive regulation of type IIa hypersensitivity; positive regulation of type III hypersensitivity; receptor-mediated endocytosis; regulation of immune response; response to bacterium
Reference #:  P26151 (UniProtKB)
Alt. Names/Synonyms: AI323638; AV092959; CD64; Fc receptor, IgG, high affinity I; Fc-gamma RI; Fcg1; Fcgam; FcgammaRI; Fcgr1; FCGR1A; FcRI; High affinity immunoglobulin gamma Fc receptor I; IgG Fc receptor I; IgG high affinity Fc receptor; IGGHAFC
Gene Symbols: Fcgr1
Molecular weight: 44,888 Da
Basal Isoelectric point: 5.73  Predict pI for various phosphorylation states
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FCGR1A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene