APOBEC1 Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Belongs to the cytidine and deoxycytidylate deaminase family. Expressed exclusively in the small intestine. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation; EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding
Chromosomal Location of mouse Ortholog: 6 F1|6 57.68 cM
Cellular Component:  apolipoprotein B mRNA editing enzyme complex; cytoplasm; mRNA editing complex; nucleus
Molecular Function:  catalytic activity; cytidine deaminase activity; cytosine deaminase activity; enzyme activator activity; hydrolase activity; metal ion binding; mRNA 3'-UTR AU-rich region binding; mRNA binding; protein binding; protein domain specific binding; ribonucleoprotein complex binding; RNA binding; zinc ion binding
Biological Process:  cytidine to uridine editing; defense response to virus; DNA cytosine deamination; DNA demethylation; establishment of localization in cell; lipoprotein biosynthetic process; lipoprotein metabolic process; lipoprotein transport; mRNA modification; mRNA processing; mRNA stabilization; negative regulation of DNA methylation-dependent heterochromatin formation; negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; negative regulation of triglyceride metabolic process; positive regulation of DNA demethylation; positive regulation of mRNA modification; regulation of cell population proliferation; response to calcium ion; response to ethanol; response to gamma radiation; response to xenobiotic stimulus; triglyceride metabolic process
Reference #:  P51908 (UniProtKB)
Alt. Names/Synonyms: ABEC1; Apobec1; apolipoprotein B editing complex 1; apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1; Apolipoprotein B mRNA-editing enzyme 1; C->U-editing enzyme APOBEC-1; Cdar1; mRNA(cytosine(6666)) deaminase 1; OTTMUSP00000029041; OTTMUSP00000029042
Gene Symbols: Apobec1
Molecular weight: 27,522 Da
Basal Isoelectric point: 8.97  Predict pI for various phosphorylation states
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APOBEC1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein