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SCG3
Member of the granin protein family that regulates the biogenesis of secretory granules. Acts as a sorting receptor for intragranular proteins including chromogranin A/CHGA. May also play a role in angiogenesis. Promotes endothelial proliferation, migration and tube formation through MEK/ERK signaling pathway. Expressed in brain, heart, kidney, liver and skeletal muscle. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Secreted; Secreted, signal peptide |
| Chromosomal Location of human Ortholog: 15q21.2 |
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Cellular Component:
endoplasmic reticulum lumen; extracellular region; secretory granule lumen; secretory granule membrane; transport vesicle membrane
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Molecular Function:
protein binding
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Biological Process:
protein localization to secretory granule
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Reference #:
Q8WXD2
(UniProtKB)
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Alt. Names/Synonyms: FLJ90833; SCG3; Secretogranin III; Secretogranin-3; SgIII
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Gene Symbols: SCG3
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Molecular weight:
53,005 Da
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Basal Isoelectric point:
4.94
Predict pI for various phosphorylation states
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