ANXA1 Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing. Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors. Contributes to the adaptive immune response by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation of activated T-cells. Promotes the differentiation of T-cells into Th1 cells and negatively regulates differentiation into Th2 cells. Has no effect on unstimulated T cells. Promotes rearrangement of the actin cytoskeleton, cell polarization and cell migration. Negatively regulates hormone exocytosis via activation of the formyl peptide receptors and reorganization of the actin cytoskeleton. Has high affinity for Ca(2+) and can bind up to eight Ca(2+) ions. Displays Ca(2+)-dependent binding to phospholipid membranes. Plays a role in the formation of phagocytic cups and phagosomes. Plays a role in phagocytosis by mediating the Ca(2+)-dependent interaction between phagosomes and the actin cytoskeleton. Belongs to the annexin family. Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver. Note: This description may include information from UniProtKB.
Protein type: Calcium-binding; Lipid-binding
Chromosomal Location of mouse Ortholog: 19 B|19 13.83 cM
Cellular Component:  apical plasma membrane; cell projection; cell surface; cilium; cornified envelope; cytoplasm; cytoplasmic vesicle; cytosol; endosome; extracellular exosome; extracellular region; extracellular space; extrinsic component of external side of plasma membrane; extrinsic component of membrane; lateral plasma membrane; mast cell granule; membrane; mitochondrial membrane; motile cilium; nucleoplasm; nucleus; plasma membrane; protein-containing complex; sarcolemma; synaptic membrane
Molecular Function:  calcium ion binding; calcium-dependent phospholipid binding; calcium-dependent protein binding; DNA/DNA annealing activity; double-stranded DNA-dependent ATPase activity; metal ion binding; phospholipase A2 inhibitor activity; phospholipase inhibitor activity; phospholipid binding; protein binding; protein binding, bridging; protein homodimerization activity; single-stranded DNA binding; structural molecule activity
Biological Process:  actin cytoskeleton reorganization; adaptive immune response; alpha-beta T cell differentiation; arachidonic acid secretion; cell surface receptor signaling pathway; cellular response to glucocorticoid stimulus; cellular response to hydrogen peroxide; cellular response to vascular endothelial growth factor stimulus; DNA duplex unwinding; endocrine pancreas development; estrous cycle; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; gliogenesis; granulocyte chemotaxis; hepatocyte differentiation; immune system process; inflammatory response; innate immune response; insulin secretion; keratinocyte differentiation; monocyte chemotaxis; myoblast migration involved in skeletal muscle regeneration; negative regulation of exocytosis; negative regulation of interleukin-8 secretion; negative regulation of phospholipase A2 activity; negative regulation of protein secretion; negative regulation of T-helper 2 cell differentiation; neutrophil clearance; neutrophil homeostasis; peptide cross-linking; phagocytosis; positive regulation of apoptotic process; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of G1/S transition of mitotic cell cycle; positive regulation of interleukin-2 production; positive regulation of neutrophil apoptotic process; positive regulation of prostaglandin biosynthetic process; positive regulation of T cell proliferation; positive regulation of T-helper 1 cell differentiation; positive regulation of vesicle fusion; positive regulation of wound healing; prolactin secretion; prostate gland development; regulation of cell proliferation; regulation of cell shape; regulation of hormone secretion; regulation of inflammatory response; regulation of interleukin-1 production; regulation of leukocyte migration; response to drug; response to estradiol; response to interleukin-1; response to peptide hormone; response to X-ray; signal transduction
Reference #:  P10107 (UniProtKB)
Alt. Names/Synonyms: Annexin A1; Annexin I; Annexin-1; Anx; Anx-1; Anx-A1; Anx1; Anxa1; C430014K04Rik; Calpactin II; Calpactin-2; Chromobindin-9; lipocortin 1; Lipocortin I; Lpc; Lpc-1; Lpc1; p35; Phospholipase A2 inhibitory protein
Gene Symbols: Anxa1
Molecular weight: 38,734 Da
Basal Isoelectric point: 6.97  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene