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AMPKB1
Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). Belongs to the 5'-AMP-activated protein kinase beta subunit family. Note: This description may include information from UniProtKB.
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| Protein type: Autophagy; Protein kinase, regulatory subunit |
| Chromosomal Location of human Ortholog: 12q24.23 |
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Cellular Component:
cytoplasm; cytosol; nucleoplasm; nucleotide-activated protein kinase complex; nucleus
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Molecular Function:
protein binding; protein kinase activity; protein kinase binding
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Biological Process:
cellular response to nutrient levels; fatty acid biosynthetic process; nail development; positive regulation of cold-induced thermogenesis; positive regulation of gene expression; protein phosphorylation; signal transduction
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Reference #:
Q9Y478
(UniProtKB)
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Alt. Names/Synonyms: 5'-AMP-activated protein kinase beta-1 subunit; 5'-AMP-activated protein kinase subunit beta-1; AAKB1; AMP-activated protein kinase beta subunit; AMPK; AMPK beta -1 chain; AMPK beta 1; AMPK subunit beta-1; AMPKb; AMPKB1; HAMPKb; MGC17785; PRKAB1; protein kinase AMP-activated non-catalytic subunit beta 1; protein kinase, AMP-activated, beta 1 non-catalytic subunit; protein kinase, AMP-activated, noncatalytic, beta-1
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Gene Symbols: PRKAB1
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Molecular weight:
30,382 Da
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Basal Isoelectric point:
5.94
Predict pI for various phosphorylation states
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CST Pathways:
AMPK Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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