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NNMT
Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas. Note: This description may include information from UniProtKB.
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| Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.1.1.1; Methyltransferase |
| Chromosomal Location of human Ortholog: 11q23.2 |
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Cellular Component:
cytosol
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Molecular Function:
nicotinamide N-methyltransferase activity; pyridine N-methyltransferase activity
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Biological Process:
animal organ regeneration; methylation; NAD biosynthesis via nicotinamide riboside salvage pathway; response to drug; response to organonitrogen compound
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Reference #:
P40261
(UniProtKB)
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Alt. Names/Synonyms: Nicotinamide N-methyltransferase; NNMT
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Gene Symbols: NNMT
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Molecular weight:
29,574 Da
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Basal Isoelectric point:
5.56
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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