NNMT Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds. Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. Predominantly expressed in the liver. A lower expression is seen in the kidney, lung, skeletal muscle, placenta and heart. Not detected in the brain or pancreas. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.1.1.1; Methyltransferase
Chromosomal Location of human Ortholog: 11q23.2
Cellular Component:  cytosol
Molecular Function:  nicotinamide N-methyltransferase activity; pyridine N-methyltransferase activity
Biological Process:  animal organ regeneration; methylation; NAD biosynthesis via nicotinamide riboside salvage pathway; response to drug; response to organonitrogen compound
Reference #:  P40261 (UniProtKB)
Alt. Names/Synonyms: Nicotinamide N-methyltransferase; NNMT
Gene Symbols: NNMT
Molecular weight: 29,574 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NNMT

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene