FDFT1 Belongs to the phytoene/squalene synthase family. Widely expressed. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase; Transferase
Chromosomal Location of human Ortholog: 8p23.1
Cellular Component:  endoplasmic reticulum; endoplasmic reticulum membrane; membrane
Molecular Function:  farnesyl-diphosphate farnesyltransferase activity; metal ion binding; protein binding; squalene synthase activity
Biological Process:  cholesterol biosynthetic process; farnesyl diphosphate metabolic process; steroid biosynthetic process
Disease: Squalene Synthase Deficiency
Reference #:  P37268 (UniProtKB)
Alt. Names/Synonyms: DGPT; ERG9; Farnesyl-diphosphate farnesyltransferase; farnesyl-diphosphate farnesyltransferase 1; FDFT; FDFT1; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; SQS; SQSD; Squalene synthase; squalene synthetase; SS
Gene Symbols: FDFT1
Molecular weight: 48,115 Da
Basal Isoelectric point: 6.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB