| FDFT1 Belongs to the phytoene/squalene synthase family. Widely expressed. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: EC 2.5.1.21; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase; Transferase |
| Chromosomal Location of human Ortholog: 8p23.1 |
| Cellular Component: endoplasmic reticulum; endoplasmic reticulum membrane; membrane |
| Molecular Function: farnesyl-diphosphate farnesyltransferase activity; metal ion binding; protein binding; squalene synthase activity |
| Biological Process: cholesterol biosynthetic process; farnesyl diphosphate metabolic process; steroid biosynthetic process |
| Disease: Squalene Synthase Deficiency |
| Reference #: P37268 (UniProtKB) |
| Alt. Names/Synonyms: DGPT; ERG9; Farnesyl-diphosphate farnesyltransferase; farnesyl-diphosphate farnesyltransferase 1; FDFT; FDFT1; FPP:FPP farnesyltransferase; presqualene-di-diphosphate synthase; SQS; SQSD; Squalene synthase; squalene synthetase; SS |
| Gene Symbols: FDFT1 |
| Molecular weight: 48,115 Da |
| Basal Isoelectric point: 6.1 Predict pI for various phosphorylation states |
| Select Structure to View Below |
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FDFT1 |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Reactome
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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