CP110 Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2. Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 7|7 F2
Cellular Component:  cell projection; centriole; centrosome; cilium; cytoplasm; cytoskeleton; microtubule organizing center; protein-containing complex
Molecular Function:  protein binding
Biological Process:  cell projection organization; centriole replication; centrosome duplication; ciliary basal body organization; negative regulation of cilium assembly; positive regulation of cilium assembly; regulation of cytokinesis
Reference #:  Q7TSH4 (UniProtKB)
Alt. Names/Synonyms: 6330503K22Rik; AA415922; AI427129; AW557948; CE110; Centriolar coiled-coil protein of 110 kDa; Centrosomal protein of 110 kDa; Cep110; Cp110; Kiaa0419; OTTMUSP00000031985; RIKEN cDNA 6330503K22 gene
Gene Symbols: CCP110
Molecular weight: 111,139 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene