ALK a tyrosine kinase of the ALK family. Plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. Translocated and expressed as a fusion protein in anaplastic lymphoma. About one third of large-cell lymphomas are caused by a t(2;5)(p23;q35) translocation that fuses ALK to nucleophosmin (NPM1A). Other cases caused by fusions of ALK to moesin, non-muscle myosin heavy chain 9, clathrin heavy chain and other genes. Several fusions also seen in inflammatory myofibroblastic tumors, and expression has been briefly noted in a range of tumors Note: This description may include information from UniProtKB.
Protein type: Alk family; EC; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group
Chromosomal Location of Human Ortholog: 17 E1.3|17 43.77 cM
Cellular Component:  axon; cell body; integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; protein-containing complex; receptor complex
Molecular Function:  ATP binding; identical protein binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process:  activation of MAPK activity; adult behavior; brain development; hippocampus development; nervous system development; neuron development; phosphorylation; positive regulation of dendrite development; protein autophosphorylation; protein phosphorylation; regulation of cell proliferation; regulation of dopamine receptor signaling pathway; regulation of neuron differentiation; response to environmental enrichment; signal transduction; swimming behavior; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P97793 (UniProtKB)
Alt. Names/Synonyms: Alk; ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246; Tcrz
Gene Symbols: Alk
Molecular weight: 174,948 Da
Basal Isoelectric point: 6.5  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene