WNT16 Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule which affects the development of discrete regions of tissues. Is likely to signal over only few cell diameters. Belongs to the Wnt family. Isoform Wnt-16b is expressed in peripheral lymphoid organs such as spleen, appendix, and lymph nodes, in kidney but not in bone marrow. Isoform Wnt-16a is expressed at significant levels only in the pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 6|6 A3.1
Cellular Component:  cytoplasm; extracellular region; extracellular space
Molecular Function:  frizzled binding; signaling receptor binding
Biological Process:  bone remodeling; cardiac epithelial to mesenchymal transition; cell fate commitment; keratinocyte differentiation; keratinocyte proliferation; multicellular organism development; negative regulation of cell death; neuron differentiation; oxidative stress-induced premature senescence; positive regulation of gene expression; positive regulation of JNK cascade; positive regulation of phosphatidylinositol 3-kinase signaling; replicative senescence; Wnt signaling pathway
Reference #:  Q9QYS1 (UniProtKB)
Alt. Names/Synonyms: E130309I19Rik; Protein Wnt-16; wingless-related MMTV integration site 16; Wnt16
Gene Symbols: Wnt16
Molecular weight: 40,727 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
CST Pathways:  ESC Pluripotency and Differentiation  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K  |  Wnt/ß-Catenin Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene