FOXO4 Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of mouse Ortholog: X D|X 43.89 cM
Cellular Component:  cytoplasm; cytosol; nuclear speck; nucleus
Molecular Function:  beta-catenin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; enzyme binding; identical protein binding; promoter-specific chromatin binding; protein binding; sequence-specific DNA binding; transcription factor binding
Biological Process:  cell cycle; cell cycle arrest; cell differentiation; glucose homeostasis; insulin receptor signaling pathway; mitotic G2 DNA damage checkpoint; multicellular organism development; muscle organ development; negative regulation of angiogenesis; negative regulation of cell proliferation; negative regulation of G0 to G1 transition; negative regulation of smooth muscle cell differentiation; negative regulation of transcription by RNA polymerase II; positive regulation of cell cycle arrest; positive regulation of smooth muscle cell migration; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; stem cell differentiation
Reference #:  Q9WVH3 (UniProtKB)
Alt. Names/Synonyms: Afx; Afx1; Afxh; Fkhr3; Fork head domain transcription factor AFX1; forkhead box O4; Forkhead box protein O4; forkhead protein; Fox; Foxo4; MGC117660; Mll; Mllt7; myeloid/lymphoid or mixed lineage-leukemia translocation to 7 homolog
Gene Symbols: Foxo4
Molecular weight: 53,649 Da
Basal Isoelectric point: 5.28  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene