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KATNB1
Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. Belongs to the WD repeat KATNB1 family. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of human Ortholog: 16q21 |
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Cellular Component:
centrosome; cytoplasm; cytosol; growth cone; katanin complex; microtubule; microtubule cytoskeleton; midbody; neuronal cell body; plasma membrane; spindle; spindle pole
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Molecular Function:
ATPase regulator activity; dynein complex binding; microtubule binding; protein binding; protein heterodimerization activity
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Biological Process:
cell division; cytoplasmic microtubule organization; microtubule depolymerization; microtubule severing; mitotic chromosome movement towards spindle pole; negative regulation of microtubule depolymerization; positive regulation of cell death; positive regulation of microtubule depolymerization; positive regulation of neuron projection development; protein targeting
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Disease: Lissencephaly 6, With Microcephaly
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Reference #:
Q9BVA0
(UniProtKB)
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Alt. Names/Synonyms: KAT; katanin (80 kDa); katanin p80 (WD repeat containing) subunit B 1; katanin p80 (WD40-containing) subunit B 1; Katanin p80 subunit B1; Katanin p80 WD40 repeat-containing subunit B1; Katanin p80 WD40-containing subunit B1; katanin regulatory subunit B1; KATNB1; KTNB1; LIS6; p80 katanin
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Gene Symbols: KATNB1
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Molecular weight:
72,334 Da
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Basal Isoelectric point:
7.51
Predict pI for various phosphorylation states
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