RECQL DNA helicase that may play a role in the repair of DNA that is damaged by ultraviolet light or other mutagens. Exhibits a magnesium-dependent ATP-dependent DNA-helicase activity that unwinds single- and double-stranded DNA in a 3'-5' direction. Belongs to the helicase family. RecQ subfamily. High expression in heart, lung, skeletal muscle and kidney, low expression in brain. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; EC; Helicase
Chromosomal Location of human Ortholog: 12p12.1
Cellular Component:  chromosome; cytoplasm; nucleoplasm; nucleus
Molecular Function:  3'-5' DNA helicase activity; ATP binding; ATP hydrolysis activity; DNA helicase activity; DNA/DNA annealing activity; four-way junction helicase activity; protein binding
Biological Process:  DNA duplex unwinding; DNA recombination; DNA repair; DNA unwinding involved in DNA replication; double-strand break repair via homologous recombination
Reference #:  P46063 (UniProtKB)
Alt. Names/Synonyms: ATP-dependent DNA helicase Q1; DNA helicase Q1-like; DNA helicase, RecQ-like type 1; DNA-dependent ATPase Q1; RecQ helicase-like; RecQ like helicase; RecQ protein-like; RecQ protein-like (DNA helicase Q1-like); RecQ protein-like 1; RECQ1; RECQL; RECQL1
Gene Symbols: RECQL
Molecular weight: 73,457 Da
Basal Isoelectric point: 8.13  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein