PPT1 Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons. Belongs to the palmitoyl-protein thioesterase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Lipid Metabolism - fatty acid elongation in mitochondria
Chromosomal Location of human Ortholog: 1p34.2
Cellular Component:  axon; cytosol; dendrite; extracellular region; Golgi apparatus; intracellular membrane-bounded organelle; lysosomal lumen; lysosome; membrane raft; neuronal cell body; nucleus; synaptic vesicle
Molecular Function:  lysophosphatidic acid binding; palmitoyl-(protein) hydrolase activity; palmitoyl-CoA hydrolase activity; protein binding; sulfatide binding; thiolester hydrolase activity
Biological Process:  adult locomotory behavior; associative learning; brain development; cellular macromolecule catabolic process; fatty-acyl-CoA biosynthetic process; grooming behavior; lipid catabolic process; lysosomal lumen acidification; membrane raft organization; negative regulation of apoptotic process; negative regulation of cell growth; negative regulation of neuron apoptotic process; nervous system development; neuron development; neurotransmitter secretion; pinocytosis; positive regulation of pinocytosis; positive regulation of receptor-mediated endocytosis; protein catabolic process; protein depalmitoylation; protein transport; receptor-mediated endocytosis; regulation of phospholipase A2 activity; regulation of synapse structure or activity; response to stimulus; sphingolipid catabolic process; visual perception
Disease: Ceroid Lipofuscinosis, Neuronal, 1
Reference #:  P50897 (UniProtKB)
Alt. Names/Synonyms: ceroid-palmitoyl-palmitoyl-protein thioesterase 1; CLN1; INCL; Palmitoyl-protein hydrolase 1; Palmitoyl-protein thioesterase 1; PPT; PPT-1; PPT1
Gene Symbols: PPT1
Molecular weight: 34,193 Da
Basal Isoelectric point: 6.07  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein