|
WARS2
Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis. Belongs to the class-I aminoacyl-tRNA synthetase family. Brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Amino Acid Metabolism - tryptophan; Aminoacyl-tRNA synthetase; EC 6.1.1.2; Ligase; Mitochondrial; Translation; Translation regulation |
| Chromosomal Location of human Ortholog: 1p12 |
|
Cellular Component:
mitochondrial matrix; mitochondrion; nucleoplasm; plasma membrane
|
|
Molecular Function:
ATP binding; tryptophan-tRNA ligase activity
|
|
Biological Process:
mitochondrial tryptophanyl-tRNA aminoacylation; positive regulation of angiogenesis; tRNA aminoacylation for protein translation; tryptophanyl-tRNA aminoacylation; vasculogenesis
|
|
Disease: Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures; Parkinsonism-dystonia 3, Childhood-onset
|
|
Reference #:
Q9UGM6
(UniProtKB)
|
|
Alt. Names/Synonyms: (Mt)TrpRS; mtTrpRS; NEMMLAS; SYWM; TrpRS; tryptophan tRNA ligase 2, mitochondrial; Tryptophan--tRNA ligase; Tryptophan--tRNA ligase, mitochondrial; tryptophan-tRNA ligase; tryptophanyl tRNA synthetase 2, mitochondrial; Tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase, mitochondrial; WARS2
|
|
Gene Symbols: WARS2
|
|
Molecular weight:
40,147 Da
|
|
Basal Isoelectric point:
9.31
Predict pI for various phosphorylation states
|
