WARS2 Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis. Belongs to the class-I aminoacyl-tRNA synthetase family. Brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - tryptophan; Aminoacyl-tRNA synthetase; EC; Ligase; Mitochondrial; Translation; Translation regulation
Chromosomal Location of human Ortholog: 1p12
Cellular Component:  mitochondrial matrix; mitochondrion; nucleoplasm; plasma membrane
Molecular Function:  ATP binding; tryptophan-tRNA ligase activity
Biological Process:  mitochondrial tryptophanyl-tRNA aminoacylation; positive regulation of angiogenesis; tRNA aminoacylation for protein translation; tryptophanyl-tRNA aminoacylation; vasculogenesis
Disease: Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures; Parkinsonism-dystonia 3, Childhood-onset
Reference #:  Q9UGM6 (UniProtKB)
Alt. Names/Synonyms: (Mt)TrpRS; mtTrpRS; NEMMLAS; SYWM; TrpRS; tryptophan tRNA ligase 2, mitochondrial; Tryptophan--tRNA ligase; Tryptophan--tRNA ligase, mitochondrial; tryptophan-tRNA ligase; tryptophanyl tRNA synthetase 2, mitochondrial; Tryptophanyl-tRNA synthetase; Tryptophanyl-tRNA synthetase, mitochondrial; WARS2
Gene Symbols: WARS2
Molecular weight: 40,147 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene