NETO2 Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16q12.1
Cellular Component:  integral component of membrane; postsynaptic density
Molecular Function:  ionotropic glutamate receptor binding
Reference #:  Q8NC67 (UniProtKB)
Alt. Names/Synonyms: Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 2; BTCL2; FLJ10430; FLJ14724; FLJ90456; NEOT2; NETO2; neuropilin (NRP) and tolloid (TLL)-like 2; Neuropilin and tolloid-like protein 2
Gene Symbols: NETO2
Molecular weight: 59,393 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
Select Structure to View Below

NETO2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein